Custom Synthesis
Epichem provides customs synthesis of both known and novel compounds on a scale of a few milligrams up to about 1kg. We offer a range of custom synthesis services including design and synthesis of analogue libraries for drug discovery programs, synthesis of haptens, metabolites, degradants, high purity standards, intermediates and other small molecules.
Epichem has a broad range of expertise in synthetic chemistry, in particular our strengths lie in the following areas:
- Aromatic chemistry, especially polyfunctional benzene and naphthalene derivatives
- Heterocyclic chemistry, especially diazines and furans
- Organometallic chemistry and Pd-catalyzed reactions
- Quinones, especially naphthoquinones
- Steroid chemistry
- Deuterated and 13C labelled compounds
- Sulphur chemistry, especially sulphonamides
- Cyclopropane chemistry
- Reactive intermediates, especially benzynes
Our experienced and professional team of chemists has an excellent track record of providing custom synthesis services to global clients, with projects ranging from small fixed price syntheses to large multiple-chemist research projects. Our chemists can design new synthetic routes or optimise existing ones to make them more amenable to scale up, often reducing the number of steps required, significantly reducing reactor time and cost.
Epichem's two state of the art laboratories are equipped with some of the best equipment available for the synthesis of drug analogues and other small molecules. Our extensive array of parallel synthesis equipment, including 6, 12, 24 and 48 position reaction stations as well as extensive SynPhaseTM handling equipment means that we can prepare your analogues more quickly and cost effectively than other laboratories. To further enhance productivity our Flashmaster II automated chromatography system can rapidly purify up to 10 compounds in a single run. To allow for the efficient scale-up synthesis of intermediates and final products, Epichem has a number of full height fumehoods and a range of reaction vessels up to 20L in size.
In addition to our extensive range of synthesis equipment, Epichem has a range of dedicated analytical instruments to examine structure and purity of synthesised compounds, including NMR, HPLC, LC/MS and GC/MS. To ensure rapid throughput of samples, all these instruments are fitted with autosamplers.
Epichem Pty Ltd provides highly specialised synthetic and medicinal chemistry services to the global drug discovery and pharmaceutical industries. 
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